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pentobarbital will improve the stage or influence of clopidogrel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will lower the extent or outcome of irinotecan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.The use of barbiturates as a sleep-inducing drug is currentl